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Thus, irradiated cells with inactivated p53 will enter mitosis with unrepaired DNA damage, resulting in mitotic catastrophe rather than immediate apoptosis or senescence (Ianzini et al., 2006)

This section will adopt a hierarchical approach, beginning with molecular-level indicators, e.g., genomics and proteomics, and progressing toward higher-order systems, including cognitive and behavioral assessments and emerging modalities such as radioligand-based imaging of synaptic density [503505]

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Ultimately, all described mitochondrial therapeutics demonstrated some degree of benefit in RGC neuroprotection and survival (Thaler et al., 2010

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